Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosis

CONCLUSION: These results suggested that PM2.5 exposure triggered the activation of NLRP3 inflammasome and pyroptosis under ischemic conditions, which may be mediated by increased ROS production after ischemic stroke. These findings may provide a more enhanced understanding of the interplay between PM2.5 and neuroinflammation and cell death, and reveal a novel mechanism of PM2.5-mediated toxic effects after ischemic stroke.PMID:35403328 | DOI:10.1111/cns.13837

Source: CNS Neuroscience and Therapeutics - April 11, 2022 Category: Neuroscience Authors: Li Gao Jie-Xing Qin Jian-Quan Shi Teng Jiang Fei Wang Chong Xie Qing Gao Nan Zhi Qing Dong Yang-Tai Guan Source Type: research