Genetic heterogeneity on sleep disorders in Parkinson ’s disease: a systematic review and meta-analysis

AbstractA growing amount of evidence has indicated contributions of variants in causative genes of Parkinson ’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to investigate the role of genetics in sleep disorders in PD patients and asymptomatic carriers at prodromal stage of PD. A systematic review and meta-analysis of observational studies was conducted based on the MEDLINE, EMBASE and PsychINFO databases. A pooled effect size was calculated by odds ratio (OR) and standard mean difference (SMD). Forty studies were selected for quantitative analysis, including 17 studies on glucocerebrosidase (GBA), 25 studies on Leucine-rich repeat kinase 2 (LRRK2) and 7 on parkin (PRKN) genes, and 3 studies on alpha-synuclein gene (SNCA) were used for qualitative analysis. Patients with PD carryingGBA variants had a significantly higher risk for rapid-eye-movement behavior disorders (RBD) (OR, 1.82) and higher RBD Screening Questionnaire scores (SMD, 0.33). Asymptomatic carriers ofGBA variants had higher severity of RBD during follow-up. Patients with PD carrying theLRRK2 G2019S variant had lower risk and severity of RBD compared with those withoutLRRK2 G2019S. Variants ofGBA,LRRK2 andPRKN did not increase or decrease the risk and severity of excessive daytime sleepiness and restless legs syndrome in PD. Our findings suggest that the genetic heterogeneity plays a role in the development of sleep disorders, mainly RBD, in PD a...
Source: Translational Neurodegeneration - Category: Neurology Source Type: research