Improvement of resistance to oxaliplatin by vorinostat in human colorectal cancer cells through inhibition of Nrf2 nuclear translocation

In conclusion, this study demonstrated that SAHA improved L-OHP resistance by inhibiting Nrf2-Keap1 activation via Nrf2 nuclear translocation by L-OHP metabolite.PMID:35358872 | DOI:10.1016/j.bbrc.2022.03.070

Source: Cell Research - March 31, 2022 Category: Cytology Authors: Shota Tanaka Mika Hosokawa Ai Tatsumi Shiho Asaumi Ryoji Imai Ken-Ichi Ogawara Source Type: research