Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus
Horm Metab Res DOI: 10.1055/a-1759-3554Zinc-α2-glycoprotein (ZAG) is an adipokine involved in body metabolism,
and now it has been shown to be present in the brain and play a role in some
neurological diseases such as epilepsy and Alzheimer’s disease. In the
present study, we employed ZAG knockout (KO) mice to investigate the effects of
ZAG on behaviors after fasting and in vitro used overexpression (OV) ZAG in
HT-22 cells to further clarify the possibly underlying mechanism. The results
showed that ZAG exists widely in the brain tissues of mice and significantly
increased during fasting. In ZAG KO group the depression-like behaviors were
significantly increased after fasting for 24 hours, meanwhile the
hippocampal reactive oxygen species (ROS) content was significantly increased.
In vitro, serum deprivation led to the increasing of neuronal death and ROS, the
reduced mitochondrial membrane potential and ATP levels, while ZAG
overexpression alleviated these negative effects. The β3 adrenoreceptor
(β3AR)/protein kinase A (PKA)/cAMP response
element-binding (CREB) pathway possibly mediated the effects of ZAG on
antioxidation. These results proposed a possible target for novel therapeutic
approaches to the treatment of depression and provide potential link between
adipose tissue and psychiatric disease. [...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Sun, Huangbing Ma, Fuli Chen, Wenjing Yang, Xiaojing Tags: Original Article: Endocrine Research Source Type: research
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