Epigenetic Aging in Early Life: Role of Maternal and Early Childhood Nutrition

This article reviews the current evidence regarding maternal and early childhood nutritional exposures and their role in epigenetic aging.Recent FindingsMaternal and early life consumption of diets higher in fiber, antioxidants, polyphenols, B vitamins, vitamin D, and ω-3 fatty acids is associated with slower epigenetic aging. Conversely, diets higher in glycemic load, fat, saturated fat, and ω-6 fatty acids demonstrate a positive association with epigenetic aging.SummaryMaternal and early life nutrition directly and indirectly influences epigenetic aging via changes in one-carbon metabolism, cardiometabolic health, and the microbiome. Clinical trials are warranted to determine the specific foods, dietary patterns, and dietary supplements that will normalize or lower epigenetic aging across the life course.
Source: Current Nutrition Reports - Category: Nutrition Source Type: research