Rag GTPases regulate cellular amino acid homeostasis [Cell Biology]

Amino acids are essential sources for synthesizing proteins, being precursors for hormones/neurotransmitters and key anaplerotic metabolites for the tricarboxylic acid cycle and gluconeogenesis. While mammalian cells can synthesize the majority of amino acids from other metabolic intermediates, among the 20 proteinogenic l-amino acids, 9 amino acids are required to be...

http://www.pnas.org/content/119/8/e2200788119.short?rss=1

Source: Proceedings of the National Academy of Sciences - February 17, 2022 Category: Science Authors: Ken Inoki, Kun-Liang Guan Tags: Cell Biology, Commentaries Commentary Source Type: research