A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor

Conclusions Surgery is the mainstay of treatment for early-stage PSTT and ETT. For patients with advanced disease or for those with poor prognostic indicators, such as an antecedent pregnancy interval of greater than 48 months, a multimodal treatment paradigm of surgery and chemotherapy using a high-risk GTN platinum-etoposide containing regimen is recommended. Relevance Placental site trophoblastic tumor and ETT should be considered in the differential diagnosis in a reproductive age patient presenting with abnormal uterine bleeding and an elevated β-hCG after any antecedent pregnancy event. Target Audience Obstetricians and gynecologists, family physicians Learning Objectives After participating in this activity, the reader should be better able to identify the presentation and diagnosis of PSTT and ETT; explain how PSTT and ETT differ from the more common forms of GTN; and describe how surgical resection is the primary treatment modality for PSTT and ETT.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research