Progranulin promotes hippocampal neurogenesis and alleviates anxiety-like behavior and cognitive impairment in adult mice subjected to cerebral ischemia

CONCLUSIONS: Progranulin alleviates ischemia-induced anxiety-like behavior and spatial learning and memory impairment in mice, probably via stimulation of hippocampal neurogenesis mediated by activation of MAPK/ERK and PI3K/Akt pathways. PGRN might be a promising candidate for coping with ischemic stroke-induced mood and cognitive impairment in clinic.PMID:35146924 | DOI:10.1111/cns.13810

Source: CNS Neuroscience and Therapeutics - February 11, 2022 Category: Neuroscience Authors: Siqi Sun Jinlong Zhou Zhongqi Li Yuzi Wu Hao Wang Qi Zheng Frank Adu-Nti Juan Fan Yingfang Tian Source Type: research