IL ‐34 in hepatoblastoma cells potentially promote tumor progression via autocrine and paracrine mechanisms

In conclusion, IL-34 expression in embryonal components may induce macrophage chemotaxis in a paracrine manner, and tumor cell proliferation and chemoresistance in an autocrine manner. IL-34 is a potential therapeutic target for hepatoblastoma.

Source: Cancer Medicine - February 8, 2022 Category: Cancer & Oncology Authors: Tomoaki Irie, Daiki Yoshii, Yoshihiro Komohara, Yukio Fujiwara, Masashi Kadohisa, Masaki Honda, Shinya Suzu, Toshiharu Matsuura, Kenichi Kohashi, Yoshinao Oda, Taizo Hibi Tags: RESEARCH ARTICLE Source Type: research