Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine induced ventricular arrhythmias

CD38 enzymatic activity regulates NAD+ and cADPR levels in mammalian tissues, and therefore has a prominent role in cellular metabolism and calcium homeostasis. Consequently, it is reasonable to hypothesize about its involvement in cardiovascular physiology as well as in heart related pathological conditions.

Source: Journal of Molecular and Cellular Cardiology - January 31, 2022 Category: Cytology Authors: Guillermo Agorrody, Thais R. Peclat, Gonzalo Peluso, Luis A. Gonano, Leonardo Santos, Wim van Schooten, Claudia C.S. Chini, Carlos Escande, Eduardo N. Chini, Paola Contreras Source Type: research