A Cautious View of the Benefits of Senolytic Therapies

In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. Link: https://doi.org/10.1016/S2666-7568(21)00300-7
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs