Deleterious Effect of Crossfostering in Rat Pups on Hypoxic-Ischaemic Injury Tolerance and Hypothermic Neuroprotection

In conclusion, crossfostering alters ou tcomes in our established model through reduced insult tolerance and variable neuroprotection. Crossfostering as a common breeding practice is a largely unexplored variable in animal research that may result in invalid research conclusions if inadequately adjusted for by larger group sizes. As a res ult, crossfostering is likely to be inconsistent with the principles of replacement, reduction, and refinement.
Source: Developmental Neuroscience - Category: Neuroscience Source Type: research