Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation

ConclusionsResults suggest that women with theFMR1 premutation who have a family history of FXTAS may be at increased risk for neurodegenerative disease, as indicated by age-related loss of syntactic complexity. Thus, family history of FXTAS may represent a personalized risk factor for age-related disease. Follow-up study is needed to determine whether syntactic decline is an early indicator of FXTAS specifically, as opposed to being a more general age-related cognitive decline associated with theFMR1 premutation.
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research