Humanized three-dimensional scaffold xenotransplantation models for myelodysplastic syndromes

Myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant hematopoietic stem cell disorders that predominantly affect older individuals, with an incidence of approximately 5 –13 per 100,000 persons/year [1–5]. Clinically, the disease is characterized by ineffective production of mature blood cells and an increased risk of progression to acute myeloid leukemia. The molecular pathogenesis is heterogeneous and frequently consists of the acquisition of multiple molecula r lesions in hematopoietic stem cells such as cytogenetic aberrations and recurrent mutations in genes of essential pathways, including transcription factors, RNA splicing, DNA repair, and epigenetic regulators [6,7].

Source: Experimental Hematology - December 21, 2021 Category: Hematology Authors: Eva Altrock, Carla Sens-Albert, Johann-Christoph Jann, Johanna Flach, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Arwin Mehralivand, Anna Hecht, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obl änder, Nadine Weimer, Iris Palme, Ahmed Jawhar, Cl Tags: Regular Submission Source Type: research