Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release

Conclusions
Thus, our study offers the first evidence that nNav contribute to arrhythmogenic DCR, thereby providing a conceptual basis for mechanism-based antiarrhythmic therapy.

Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Radwałski, P. B., Brunello, L., Veeraraghavan, R., Ho, H.-T., Lou, Q., Makara, M. A., Belevych, A. E., Anghelescu, M., Priori, S. G., Volpe, P., Hund, T. J., Janssen, P. M. L., Mohler, P. J., Bridge, J. H. B., Poelzing, S., Gyorke, S. Tags: Ion channels and arrhythmias Source Type: research