New COL4A5 mutation in IgA nephropathy

Conclusion
Together with other published data, we suggest that genetic screening should be performed in IgAN, particularly for patients with a familial history. The effects of different mutated splice sites of the COL4A5 gene, as well as the tissue specificity of the splicing machinery contributing to the pathogenesis and prognosis of IgAN, remains unclear and warrants further exploration in the future.

Source: Postgraduate Medical Journal - December 15, 2021 Category: General Medicine Authors: Xu, Z., Chen, J., Yu, W., Li, X., Lin, B., Lai, D., Xu, A., Tang, Y. Tags: Original research Source Type: research