Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice

Discussion An oxysterol biology-based PAM of NMDARs is able to reverse the synaptic and memory deficits caused by CSF from patients with anti-NMDAR encephalitis. These findings suggest a novel adjuvant treatment approach that deserves future clinical evaluation.

http://nn.neurology.org/cgi/content/short/9/1/e1122?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - December 13, 2021 Category: Neurology Authors: Radosevic, M., Planaguma, J., Mannara, F., Mellado, A., Aguilar, E., Sabater, L., Landa, J., Garcia-Serra, A., Maudes, E., Gasull, X., Lewis, M., Dalmau, J. Tags: Autoimmune diseases Article Source Type: research