Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial

CONCLUSION: In moderate-to-severe postsurgical dental pain, a single dose of NapS was at least as effective as HYD+APAP in the early hours, significantly more effective at reducing pain intensity and providing greater pain relief over 12 hours, and was better tolerated. When not contraindicated, NapS should be considered a preferred alternative to opioid combinations for acute pain. (ClinicalTrials.gov, Identifier: NCT04307940; https://clinicaltrials.gov/ct2/show/NCT04307940).PMID:34878953 | DOI:10.1080/00325481.2021.2008180

Source: Postgraduate Medicine - December 8, 2021 Category: Internal Medicine Authors: Stephen A Cooper Paul J Desjardins Todd Bertoch Alberto Paredes-Diaz Emanuel Troullos Azita Tajaddini Robert Centofanti Robert An Donna Morella Source Type: research