Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors

Discussion
Our study provides new evidence for the involvement of NKG2D and its ligand ULBP4 in MS pathology. Our results point to ULBP4 as a viable target to specifically block 1 component of the NKG2D pathway without altering immune surveillance involving other NKG2DL.

Source: Neurology Neuroimmunology and Neuroinflammation - December 6, 2021 Category: Neurology Authors: Carmena Moratalla, A., Carpentier Solorio, Y., Lemaitre, F., Farzam-kia, N., Levert, A., Zandee, S. E. J., Lahav, B., Guimond, J. V., Haddad, E., Girard, M., Duquette, P., Larochelle, C., Prat, A., Arbour, N. Tags: All Immunology, Autoimmune diseases, Multiple sclerosis Article Source Type: research