Diagnostic and Therapeutic Considerations Towards Dientamoeba fragilis in Children: A Survey Amongst General Practitioners and Pediatricians in the Netherlands

This study shows heterogeneity in clinical practice amongst Dutch physicians regarding diagnostic- and therapeutic approach of D fragilis in children. Different attitude towards pathogenicity and inconsistent guidelines could be causative factors.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communication: Gastroenterology Source Type: research

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Conclusion: Intestinal microbiota does not seem to play a key role in the presence of clinical symptoms in children with D. fragilis. The pathogenicity of D. fragilis and pathophysiologic pathways underlying the development of gastrointestinal symptoms remains yet to be clarified.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Abstract BACKGROUND: Blastocystis hominis (B. hominis) and Dientamoeba fragilis (D. fragilis) are two protozoan parasites of human bowel that are found throughout the world. There is still debate about the pathogenicity of these protozoans, despite them being commonly associated with gastrointestinal symptoms and can cause health issue in both children and adults. These parasites are usually transmitted through faecal-oral contact particularly under poor hygiene conditions or food/water contamination. Once a person is infected, the parasites live in the large intestine and are passed in the faeces. AIM: To in...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Authors: van Kalleveen MW, van Gool T, Klarenbeek N, Benninga MA, Savelkoul PHM, de Meij T, Plötz FB Abstract Introduction: The presence of D. fragilis in feces is characterized by asymptomatic carrier ship to a spectrum of gastrointestinal symptoms. However, a causal relationship remains to be elucidated. In this systematic review we aimed to evaluate the relationship between eradication of D. fragilis and symptoms to establish the strength of evidence that D. fragilis in symptomatic children warrants antibiotic treatment.Areas covered: This systematic review covers a challenge in daily clinical practice. Is ...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
In this study, we aimed to investigate the incidence of Dientamoeba fragilis with different diagnostic methods in patients with gastrointestinal symptoms and determine the sensitivity and specificity of existing diagnostic methods. Fecal samples collected from 101 patients with gastrointestinal complaints (especially upper abdominal pain, abdominal and pelvic pain, nausea and vomiting, gastroenteritis and colitis, unexplained fever and diarrhea) and 20 control cases from various clinics were included in the study. Samples were first examined with native-Lugol (N-L) method and cultured in Robinson medium. All 121 stool and ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
In this study, a patient with a history that eluded to possible acute GI parasitic infection, but without classic symptomology, was screened using a sodium acetate acetic acid formalin (SAF)-fixative triple-faeces test. Even though the patient's symptoms did not strongly suggest stool analysis, her history of travel was clinically relevant. The faeces test revealed the patient was positive for Blastocystis hominis, Dientamoeba fragilis trophs, Endolimax nana trophs, Entamoeba coli trophs, a-hemolytic Streptococcus, Enterobacter cloacae, Klebsiella pneumoniae, and yeast. Subsequently, the patient was treated for GI infectio...
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Authors: Windsor JJ, Macfarlane L, Hughes-Thapa G, Jones SKA, Whiteside TM Abstract Symptoms associated with Dientamoeba fragilis include diarrhoea, abdominal pain, nausea, vomiting, epigastric pain and weight loss. A possible link between D. fragilis and irritable bowel syndrome (IBS)-like symptoms has been reported, and therefore the presence of this parasite should be excluded before making a diagnosis of IBS. Over a six-month period, 976 faecal samples were submitted to NPHS Microbiology Aberystwyth for routine microbiological analysis. All samples were also cultured for parasites using Robinson's xenic medium....
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Dientamoeba fragilis is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on D. fragilis in children aged 0 to 6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009 through 2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR, D. fragilis was detected in the first stool sample from 97 of 142 (68.3%) children. We evaluated the associations between seven plausible risk factors ...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Parasitology Source Type: research
Background: Dientamoeba fragilis is a neglected intestinal protist associated with clinical outcomes in humans. There is still an obscurity about its pathogenicity in humans, including whether it can modulate immune responses, through which mechanisms it initiates infection, or it is mostly a silent resident of human gut. There are many studies and case reports which all indicate D. fragilis as the causative agent of patients with diarhhea, abdominal pain, meteorism and urticaria. Yet, D. fragilis may have pathogenic subtypes and/or act as a pathogen under certain circumstances through interaction with the host's immune system.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Poster Presentation Source Type: research
E Vassalou, CM Vassalos, G Spanakos, A Fotopoulos, G Dounias, P Kalofolias, G Vrioni, A TsakrisIndian Journal of Medical Microbiology 2016 34(1):106-108Dientamoeba fragilis is now considered a potentially emerging gastrointestinal pathogen in both developing and developed countries. We first report an autochthonous case of D. fragilis infection in Greece. A 49-year-old female with acute non-specific abdominal pain required emergency surgical admission for active observation and repeated assessment. To the best of our knowledge, this is the first reported case of acute unexplained abdominal pain finally attributed to D. fra...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Conclusion In post-traumatic healthy splenectomized patients, Blastocystis spp. were found to be the most prevalent protozoa and may be responsible for the gastrointestinal disorders. Graphical abstract
Source: Parasitology International - Category: Parasitology Source Type: research
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