Depression associated with APOE status and hippocampal volume but not cognitive decline in older adults aging with traumatic brain injury.

Conclusions: APOE carrier status was predictive of depression in a sample of older adults with a history of TBI. Depressive symptoms were also associated with decreased hippocampal volume but did not predict cognitive deficits in the examined domains beyond the effects of cognitive reserve. Despite the relationship between GDS and biological risks for decline, depressive symptoms in this population showed no direct relationship with cognitive decline. (PsycInfo Database Record (c) 2021 APA, all rights reserved)
Source: Neuropsychology - Category: Neurology Source Type: research