Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice

In this study, we sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of metabolic syndrome and its associated diseases and the impact of physical activity under metabolic syndrome progression upon the gut microbiome. Utilizing the whole-body low-density lipoprotein receptor (LDLR) knockout mice on a “Western Diet,” we show that long-term exercise acts favorably upon glucose tolerance, adiposity, and liver lipids. Our results indicate that exercise can ameliorate some aspects of the metabolic syndrome progression and alter the gut microbiome. AbstractThe metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated that an individual's gut microbiome composition has a large influence on several aspects of the metabolic syndrome. However, the mechanism(s) by which physical activity may improve metabolic health are not well understood. We sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of the metabolic syndrome and its associated diseases. We also analyzed the impact of physical activity under metabolic syndrome progression upon the gut microbiome composition. Utilizing whole-body low-density lipoprotein receptor (LDLR) knockout mice on a “Western Diet,” we show t...

Source: Physiological Reports - November 10, 2021 Category: Physiology Authors: Timothy M. Moore, Anthony Terrazas, Alexander R. Strumwasser, Amanda J. Lin, Xiaopeng Zhu, Akshay T. S. Anand, Christina Q. Nguyen, Linsey Stiles, Frode Norheim, Jennifer M. Lang, Simon T. Hui, Lorraine P. Turcotte, Zhenqi Zhou Tags: ORIGINAL ARTICLE Source Type: research