Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens

ConclusionThe recommended IV dose of 10  mg/kg q8h, not exceeding 400 mg q8h, would achieve AUC0-24  h to successfully treat bacteria with MICs  ≤ 0.25 (e.g. Salmonella, Escherichia coli, Proteus, Haemophilus, Enterobacter, and Klebsiella). A dose increase to 600 mg q8h in children >  40 kg and to 15 mg/kg q8h (max 400 mg q8h, max 600 mg q8h if augmented renal clearance, i.e., eGFR >  200 mL/min/1.73 m2) in children  
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Braz J Biol - Category: Biology Authors: Source Type: research
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Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSION: In view of the different pharmacological activity recorded, the extract of the leaves should be recommended to treat patients suffering from gastroenteriditis.PMID:34956387 | PMC:PMC8709746 | DOI:10.1155/2021/8938534
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
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Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
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Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
Conclusions There is limited research that focused on food safety at transport stations in Africa, especially on aspects such as hygiene practices, food storage and occupational health and food safety. Therefore, we recommend more research in these areas, using various primary study designs, to inform and improve food safety policies and practices for transport stations in African countries alongside improving access to clean water/handwashing facilities, and undertaking structural changes to facilitate behaviours and monitoring for unintended consequences such as livelihoods of vulnerable populations.
Source: BMJ Open - Category: General Medicine Authors: Tags: Open access, Public health Source Type: research
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