Development and validation of a novel nomogram for postoperative pulmonary complications following minimally invasive esophageal cancer surgery

This study aims to construct a nomogram based on clinical factors to predict PPCs and investigate related early outcomes. Clinical data of 969 consecutive patients receiving MIE were retrospectively collected. Univariate and multivariate analysis were performed to select independent predictors. Using independent predictors to develop a nomogram and using a bootstrap-resampling approach to conduct internal verification. Early outcomes of PPCs were analyzed. The incidence of PPCs following MIE was 39.6% (384 out of 969). In multivariate analysis, older age (Odds ratio (OR) 1.034,P 
Source: Updates in Surgery - Category: Surgery Source Type: research

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Front Cell Infect Microbiol. 2021 Nov 11;11:774330. doi: 10.3389/fcimb.2021.774330. eCollection 2021.ABSTRACTMicrobial imbalances have been well elucidated in esophageal adenocarcinoma. However, few studies address the microbiota in esophageal squamous cell carcinoma (ESCC) and esophagitis (ES). We aimed to explore the association of esophageal microbiota with these patients. Esophageal tissues were obtained from healthy controls and ES and ESCC patients undergoing upper endoscopy. 16S rRNA gene sequencing was applied to analyze the microbiome. The α and β diversity differences were tested by Tukey test and part...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
BackgroundEsophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer and the seventh most prevalent cause of cancer-related death worldwide. Tumor microenvironment (TME) has been confirmed to play an crucial role in ESCC progression, prognosis, and the response to immunotherapy. There is a need for predictive biomarkers of TME-related processes to better prognosticate ESCC outcomes.AimTo identify a novel gene signature linked with the TME to predict the prognosis of ESCC.MethodsWe calculated the immune/stromal scores of 95 ESCC samples from The Cancer Genome Atlas (TCGA) using the ESTIMATE algor...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
J Immunol. 2021 Dec 1:ji2001357. doi: 10.4049/jimmunol.2001357. Online ahead of print.ABSTRACTAdoptive T cell therapy with T cells expressing affinity-enhanced TCRs has shown promising results in phase 1/2 clinical trials for solid and hematological tumors. However, depth and durability of responses to adoptive T cell therapy can suffer from an inhibitory tumor microenvironment. A common immune-suppressive agent is TGF-β, which is secreted by tumor cells and cells recruited to the tumor. We investigated whether human T cells could be engineered to be resistant to inhibition by TGF-β. Truncating the intracellular ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
DiscussionTaken together, the increasing trend in adenocarcinoma in females in our study can be related to the increasing rate of obesity and smoking in females in recent years in our region. The incidence trend of different morphologic types of esophageal cancer is changing. This can be a consequence of alterations in the incidence trend of different risk factors. It is necessary to conduct more studies evaluating these risk factors.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
Jing Wen Jianhua Fu Esophageal squamous cell carcinoma (ESCC) is one of the deadliest malignancies in China. The prognostic value of mutations, especially those in minor tumor clones, has not been systematically investigated. We conducted targeted deep sequencing to analyze the mutation status and the cancer cell fraction (CCF) of mutations in 201 ESCC patients. Our analysis showed that the prognostic effect of mutations was relevant to the CCF, and it should be considered in prognosis prediction. EP300 was a promising biomarker for overall survival, impairing prognosis in a CCF dose-dependent manner. We constructed ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Contributors : K Tanigawa ; Y I KomaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTumor-associated macrophages enhance the malignant phenotypes of esophageal squamous cell carcinoma (ESCC) cells. We have previously identified several factors associated with ESCC progression using an indirect co-culture assay between ESCC cells and macrophages. Here, we newly established a direct co-culture assay between ESCC cells and macrophages which is closer to the actual cancer microenvironment than an indirect co-culture assay. To investigate the gene expression changes by co-culture with macrophages, we performed...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Sachin Mulmi Shrestha ; Lihua Ren ; Xin Fang ; Hui Ye ; Ruihua ShiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAltogether 12 tissue specimens were collected from Esophageal squamous cell carcinoma patients (4 normal tissues, 4 cancer adjacent tissue, 4 cancer tissue). Tissue samples were kept in RNA Later solution and preserved in liquid nitrogen. Then, tissue samples were further processed to extract mRNA,lnc RNA and circRNA profile
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Correction Source Type: research
We report the case of a 69-year-old man with a relevant alcohol consumption and history of prostate cancer performed a screening upper gastrointestinal endoscopy and colonoscopy. The upper gastrointestinal endoscopy revealed an ulcerated mass in the middle oesophagus occupying half the circumference. Histologic examination was compatible with a squamous cell carcinoma. Staging with endoscopic ultrasound and computed tomography of the neck, chest, and abdomen was consistent with a T3N1M0.PMID:34844414 | DOI:10.17235/reed.2021.8467/2021
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Authors: Source Type: research
ConclusionsMig-6 might be a new tumor suppressor gene and a possible target for the specific therapy of ESCC.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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