Lack of association between CYB5A gene rs1790834 polymorphism and the response to leflunomide in women with rheumatoid arthritis

ConclusionsThe results of our study suggest lack of statistically significant association between theCYB5A gene rs1790834 polymorphism and the response to leflunomide in women with RA.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - Category: Research Authors: Tags: Self-Experimentation Source Type: blogs
CONCLUSIONS: Significant others and the support they give are prominent factors and facilitators in everyday life of persons with RA. Concurrently, the support persons with RA provide is important, along with support from outside of the dyads.SIGNIFICANCE: The results indicate that the interaction between persons with RA and the social environment is central to gain insight into how support should be provided for optimal participation in everyday life. Significant others can preferably be more involved in the rehabilitation process.PMID:34846249 | DOI:10.1080/11038128.2021.2007997
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Authors: Source Type: research
Curr Pharm Des. 2021;27(44):4433. doi: 10.2174/138161282744211025125359.NO ABSTRACTPMID:34844530 | DOI:10.2174/138161282744211025125359
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Source Type: research
Dis Markers. 2021 Nov 20;2021:7933453. doi: 10.1155/2021/7933453. eCollection 2021.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease leading to severe joint damage and disability. Fibroblast-like synoviocytes (FLSs) mostly contribute to the joint inflammation and destruction in RA through distinct mechanisms. However, little is known about newly discovered interleukin- (IL-) 36 and IL-38 involving in the pathology of RA. Here, we assessed the effect of IL-36 and IL-38 on RA-FLS function using IL-36 and IL-38 overexpression plasmids. We found that IL-36 inhibited synoviocytes proliferation while IL-38 showed an opp...
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
Contributors : Junping Yang ; Huangxin Lu ; Yifan Yang ; Dong Kuang ; Ping LiuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensIn order to identify new biomarkers for the diagnosis of rheumatoid arthritis, we used circRNA microarray technology to screen the differential expression of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis. We identified a total of 399 differentially expressed circRNAs in RA patients and healthy controls, of which 149 circRNAs were significantly up-regulated in RA patients and 250 were down-regulated. Among them, hsa_circRNA_101328 may be a p...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Contributors : Sergio Ramirez-Perez ; Pallavi BhattaramSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: We analyzed RNA-seq from peripheral blood mononuclear cells (PBMC) in DMARDs-na ïve RA patients and healthy subjects. Our goal was to evaluate the transcriptional profiles of ST2825-treated PBMC to identify its therapeutic potential.Methods: We analyzed bulk RNA-seq from peripheral blood mononuclear cells (PBMC) in DMARDs-na ïve RA patients after stimulation with LPS and IL-1β, PBMC were treated with the MyD88 chemical inhibitor, ST2825. Collection of RNA was ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Conclusion:For the first time, we indicated that IL-21 inhibits LPS-mediated cytokine production in RA-SF MΦs, and impairs pro-inflammatory activity of M1-like macrophages, hereby exerting anti-inflammatory effects on RA. Thus, IL-21 might not be an appropriate therapeutic target for RA.PMID:34842006 | DOI:10.1080/08916934.2021.2007374
Source: Autoimmunity - Category: Allergy & Immunology Authors: Source Type: research
Expert Rev Clin Immunol. 2021 Nov 27. doi: 10.1080/1744666X.2022.2012451. Online ahead of print.ABSTRACTINTRODUCTION: : Management of Rheumatoid Arthritis(RA) has improved following implementation of early intensive treat to target recommendations and the availability of different biologicals. Most experience is with TNF blockers but challenges remain in the efficacy/safety balance, immunogenicity and long term drug survival as well as availability and affordability despite introduction of biosimilars. Area covered: We provide an overview of the development of CT-P13 SC, based on infliximab biosimilar CT-P13 IV. The one ye...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Clin Exp Rheumatol. 2021 Nov-Dec;39(6):1410-1412. Epub 2021 Nov 25.ABSTRACTA 33-year-old woman developed palindromic rheumatism (PLR) several weeks following an infection with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Three months later, she developed full blown seropositive rheumatoid arthritis (RA) following COVID-19 reinfection. Although the occurrence of the joint diseases and the COVID-19 infections maybe fortuitous, knowing the enormous effects of COVID-19 infection on the human immune system, it is difficult to ignore the temporal relationship between the appearance of PLR after the first COVID-1...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Authors: Source Type: research
AbstractInjury to the peripheral nerve is traditionally referred to acquired nerve injury as they are the result of physical trauma due to laceration, stretch, crush and compression of nerves. However, peripheral nerve injury may not be completely limited to acquired physical trauma. Peripheral nerve injury equally implies clinical conditions like Guillain-Barr é syndrome (GBS), Carpal tunnel syndrome, rheumatoid arthritis and diabetes. Physical trauma is commonly mono-neuropathic as it engages a single nerve and produces focal damage, while in the context of pathological conditions the damage is divergent involving...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
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