Upfront Alternative Donor Transplant Versus Immunosuppressive Therapy in Patients with Severe Aplastic Anemia Who Lack Fully HLA Matched Related Donor: Systematic Review and Meta-Analysis of Retrospective Studies. on Behalf of the Severe Aplastic Anemia Working Party of European Group for Blood and Marrow Transplantation (SAAWP of EBMT)

Aplastic anemia (AA) is a hematopoietic stem cell disorder characterized by decreased bone marrow cellularity and diminished hematopoiesis. It is a rare life-threatening disorder that can be acquired and idiopathic, or it can arise from a background of an inherited marrow failure syndrome. This difference in etiology has significant implications on treatment decisions and management. For instance, immunosuppression is a therapeutic option for acquired AA but is ineffective for the treatment of the inherited forms of bone marrow failure.

Source: Biology of Blood and Marrow Transplantation - October 11, 2021 Category: Hematology Authors: Hind Alotaibi, Mahmoud Aljurf, Regis de Latour, Mansour Alfayez, Andrea Bacigalupo, Riad El Fakih, Hubert Schrezenmeier, Syed Osman Ahmed, Eliane Gluckman, Shahid Iqbal, Britta H öchsmann, Constantijn Halkes, Josu de la Fuente, Nawal Alshehry, Simone Ces Source Type: research