Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

Conclusions
Progression of NASH and NASH-related hepatic mitochondrial dysfunction can be prevented by RYGB. RYGB preserves respiratory chain complex activity, thereby restoring energy output, probably by limiting the amount of oxidative stress and TNF-α. These data suggest that modulation of hepatic mitochondrial function contributes to the favourable effect of RYBG on established NASH.

Source: Gut - March 6, 2015 Category: Gastroenterology Authors: Verbeek, J., Lannoo, M., Pirinen, E., Ryu, D., Spincemaille, P., Vander Elst, I., Windmolders, P., Thevissen, K., Cammue, B. P. A., van Pelt, J., Fransis, S., Van Eyken, P., Ceuterick-De Groote, C., Van Veldhoven, P. P., Bedossa, P., Nevens, F., Auwerx, J Tags: Hepatology Source Type: research