Autonous Aldosterone Secretion as a Subclinical Form of Primary Aldosteronism: Pathogenesis and Clinical Significance
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1556-7784In recent years, a substantial prevalence of primary aldosteronism (PA) has been
demonstrated in both normotensive and mildly hypertensive cohorts. Consequently,
a classic presentation of the syndrome, i. e. moderate-to-severe
and resistant hypertension with concomitant hypokalemia, should be considered a
tip-of-the-iceberg phenotype of a wide PA spectrum. Its entire range encompasses
the non-classic clinical forms of mild hypertension and prehypertension but also
several biochemical presentations, including patients who meet PA screening and
confirmation test criteria, as well as those with either of them and those with
other parameters indicating mineralocorticoid excess. In the current review,
research insights on the pathogenetic background and clinical significance of
autonomous aldosterone secretion (AAS) are presented, which is defined as a
constellation of either: 1) normotension, normokalemia, a positive PA screening
(high aldosterone-to-renin ratio) and/or confirmation test, or 2)
hypertension, normokalemia and a positive PA screening but negative confirmation
test. For this purpose, a literature search of the PubMed database was
conducted. Advances in immunohistochemistry and genetic sequencing of isolated
adrenal cells are provided as probable morpholog...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Kmie ć, Piotr Sworczak, Krzysztof Tags: Review Source Type: research
More News: Databases & Libraries | Diabetes | Endocrinology | Genetics | Hypertension | Metabolic Syndrome | Orthopaedics | Osteoporosis | Study | Urology & Nephrology