Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

Conclusions: We define a previously unrecognized interaction of human endothelial cells and monocytes that promote formation of AS DCs in hypertension and show a critical role of GAS6 and Axl signaling in both immune cells and endothelial cells. This pathway is potentially a novel therapeutic target to reduce inflammation and end organ damage in hypertension.PMID:34565181 | DOI:10.1161/CIRCRESAHA.121.319643

Source: Circulation Research - September 27, 2021 Category: Cardiology Authors: Justin Pieter Van Beusecum Natalia Ruggeri Barbaro Charles Duncan Smart David M Patrick Roxana Loperena Shilin Zhao Nestor de la Visitacion Mingfang Ao Liang Xiao Cyndya A Shibao David G Harrison Source Type: research