Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions

Conclusion These results indicated that Annexin A2 degradation plays a crucial role the degeneration of dapaminergic cells of Parkinson’s disease, and Annexin A2 downregulation-mediated the cell death is closely associated with mitochondrial dysfunction via p53-dependent pathway; thus provide a novel therapeutic target for Parkinson’s disease treatment.
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research