The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease

The objective of the study was to explore the effect of the PARK16 rs11240572 variant on brain structure in PD patients. A total of 51 PD patients were enrolled in the study and genotyped for the rs11240572 variant. Clinical assessments and MRI scans were conducted across all participants. Voxel-based morphometry (VBM) was used to investigate gray matter volume (GMV) of the whole brain between these two groups. Correlation analysis was performed to identify the relationships between GMV and clinical features. There were 17 rs11240572-A variant carriers and 34 non-carriers, with no significant demographic differences between these two groups. Compared with non-carriers, rs11240572-A carriers showed increased GMV in the left caudate nucleus and putamen, but decreased GMV in the left superior temporal gyrus and supramarginal gyrus. In non-carriers, left basal ganglia GMV was positively correlated with UPDRS III (r = 0.365,p = 0.034) and bradykinesia (r = 0.352,p = 0.042), but negatively correlated with MMSE (r =  – 0.344,p = 0.047), while in carriers negative correlation between basal ganglia GMV and MMSE was also observed (r =  – 0.666,p = 0.004). Moreover, the GMV of left temporoparietal cortex was positively associated with cognitive function in both groups (carriers,r = 0.692,p = 0.002; non-carriers,r = 0.879,p <  0.001). When reducing the sample size of non-carriers to the level of the carrier sample, similar co...
Source: Anatomy and Embryology - Category: Anatomy Source Type: research