High Intrapatient Variability in Tacrolimus Exposure Calculated Over a Long Period Is Associated With De Novo Donor-Specific Antibody Development and/or Late Rejection in Thai Kidney Transplant Patients Receiving Concomitant CYP3A4/5 Inhibitors

Conclusions: Tac IPV6–24 was higher and more significantly associated with DSA development and/or late rejection than Tac IPV6–12, independent of Tac trough level. This is the first study to demonstrate the impact of high IPV on DSA development in Asian patients, and that Tac IPV is comparable between patients with and without CYPinh.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research

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Combined liver-kidney transplant (CKLT) is increasingly prevalent in the US. Prior studies of high acuity recipients from high volume centers suggest that delayed implantation of the kidney, with pulsatile perfusion pumping, may decrease delayed graft function (DGF) and improve kidney graft survival. Here, we sought to determine the overall effect of kidney allograft perfusion during CLKT for patients transplanted at US transplant centers.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and Tissue Engineering Source Type: research
Chronic lung allograft dysfunction (CLAD) is the major cause of death after lung transplantation. Angiotensin II (AngII), the main effector of the renin–angiotensin system, elicits fibrosis in both kidney and lung. We identified six AngII-regulated proteins (Ras homolog family member B (RHOB), bone marrow stromal cell antigen 1 (BST1), lysophospholipase 1 (LYPA1), glutamine synthetase (GLNA), thrombospondin 1 (TSP1) and laminin subunit β2 (LAMB2)) that were increased in urine of patients with kidney allograft fibrosis. We hypothesised that the renin–angiotensin system is active in CLAD and that AngII-regul...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung biology and experimental studies Original Articles: Basic science and lung transplant Source Type: research
Am J Cancer Res. 2021 Sep 15;11(9):4624-4637. eCollection 2021.ABSTRACTPost-transplant lymphoproliferative disorders (PTLD) are among the most serious complications after solid organ transplantation (SOT). Monomorphic diffuse large B-cell lymphoma (DLBCL) is the most common subtype of PTLD. Historically, outcomes of PTLD have been poor with high mortality rates and allograft loss, although this has improved in the last 10 years. Most of our understanding about PTLD DLBCL is extrapolated from studies in non-PTLD DLBCL, and while several clinical factors have been identified and validated for predicting non-PTLD DLBCL outcom...
Source: Cell Research - Category: Cytology Authors: Source Type: research
BackgroundAntigen recognition of allo-peptides and HLA molecules leads to the activation of donor-reactive T-cells following transplantation, potentially causing T-cell-mediated rejection (TCMR). Sequencing of the T-cell receptor (TCR) repertoire can be used to track the donor-reactive repertoire in blood and tissue of patients after kidney transplantation.Methods/DesignIn this prospective cohort study, 117 non-sensitized kidney transplant recipients with anti-CD25 induction were included. Peripheral mononuclear cells (PBMCs) were sampled pre-transplant and at the time of protocol or indication biopsies together with graft...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: Transplant kidney biopsy remains the gold standard in distinguishing between foscarnet crystalline glomerular and/or tubulointerstitial lesions, and various forms of rejection and other causes of impaired renal function in transplant kidney.PMID:34643504 | DOI:10.5414/CNP96S23
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Asian J Surg. 2021 Oct 7:S1015-9584(21)00570-4. doi: 10.1016/j.asjsur.2021.08.066. Online ahead of print.ABSTRACTPrimary hyperoxaluria type 2 is a rare autosomal recessive genetic disease characterized by endogenous oxalate excess caused by deficiency of glyoxalate reductase/ hydroxypyruvate reductase. The optimal form of transplantation for primary hyperoxaluria type 2 remains controversial. Herein, we described a 26-year-old man with primary hyperoxaluria type 2 confirmed by genetic testing. The patient experienced rapid and severe recurrence of oxalate nephropathy after isolated kidney transplantation. Despite extensive...
Source: Asian Journal of Surgery - Category: Surgery Authors: Source Type: research
This article reviews the best management strategies for transplant patients after a failed kidney allograft.American Journal of Transplantation
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Transplantation Journal Article Source Type: news
AbstractUsing the vascularized skin allograft (VSA) model, we compared the tolerogenic effects of different allogeneic bone marrow transplantation (BMT) delivery routes into immunoprivileged compartments under a 7-day protocol immunosuppressive therapy. Twenty-eight fully MHC mismatched VSA transplants were performed between ACI (RT1a) donors and Lewis (RT11) recipients in four groups of seven animals each, under a 7-day protocol of alfa/beta TCRmAb/CsA (alpha/beta-TCR monoclonal antibodies/Cyclosporine A therapy). Donor bone marrow cells (BMC) (100  × 106 cells) were injected into three different immun...
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research
We report the effective treatment of a para-renal AAA in a patient with a functional renal allograft.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
Clin J Am Soc Nephrol. 2021 Oct;16(10):1539-1551. doi: 10.2215/CJN.05530421.ABSTRACTBACKGROUND AND OBJECTIVES: Subclinical acute rejection is associated with poor outcomes in kidney transplant recipients. As an alternative to surveillance biopsies, noninvasive screening has been established with a blood gene expression profile. Donor-derived cellfree DNA (cfDNA) has been used to detect rejection in patients with allograft dysfunction but not tested extensively in stable patients. We hypothesized that we could complement noninvasive diagnostic performance for subclinical rejection by combining a donor-derived cfDNA and a ge...
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Source Type: research
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