Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients

We report evaluation of 30 assays ’ (17 rapid tests (RDTs) and 13 automated/manual ELISA/CLIA assay (IAs)) clinical performances with 2594 sera collected from symptomatic patients with positive SARS-CoV-2 rRT-PCR on a respiratory sample, and 1996 pre-epidemic serum samples expected to be negative. Only 4 RDT and 3 IAs fitted both specificity (> 98%) and sensitivity (> 90%) criteria according to French recommendations. Serology may offer valuable information during COVID-19 pandemic, but inconsistent performances observed among the 30 commercial assays evaluated, which underlines the importance of independent evaluation before clinical implementation.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research

Related Links:

In this report, the first case of COVID-19 positive C.auris fungemia detected in Turkey was presented. A 71-year-old male patient with a history of myocardial infarction, diabetes mellitus, donation of a single kidney and lobectomy surgery due to lung cancer was hospitalized in the pandemic thoracic surgery service due to the findings consistent with viral pneumonia on thoracic computed tomography. Favipiravir 2 x 600 mg and intravenous dexamethasone 1 x 6 mg therapy was administered. The patient tested positive for SARS-CoV-2 polymerase chain reaction, and severe involvement of the left lung was detected in the following ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Authors: Source Type: research
AbstractBackgroundAdolescents play a major role in SARS-CoV-2 spread. The study objective was to assess COVID-19 attitudes among Polish final year high school students.MethodsAn online cross-sectional survey was conducted between December 2020-March 2021; 24 high schools were randomly selected in Lubuskie region, followed by a random selection of 51 classes. Students' attitudes were assessed by an anonymous questionnaire before an online lecture on SARS-CoV-2.ResultsResponse rate was 72%, 638 students responded (360 females, mean age 18.4 ±0.6 years); 438 attended schools in towns with
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsPrevention and control measures adopted timely during the first wave were effective to limit Sars-CoV-2 spread within prison facilities. According to our findings, POs and PiP are population groups at high risk for acquiring and transmitting COVID-19 and should be prioritized for testing, active case finding and vaccination. This study highlights the importance of including prison settings within emergency preparedness plans.Key messagesStringent prevention and control measures when adopted timely were effective to protect detention facilities from Sars-CoV-2 spread.Our study, reporting the burden of COVID-19 ep...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsAccurate short-term predictions of Covid-19 patient admissions can be made, and both the symptom check questionnaires and the daily admissions data contribute to the accuracy of the predictions. Thus, symptoms checkers can be used to estimate the progression of the pandemic, which can be considered when predicting the health care burden in a future pandemic.Key messagesDigital surveillance of symptoms enables rapid and contactless tracing of epidemic progression.Prediction models can help support medical decision making in an epidemic to promote and protect public health and prevent health care system overload.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Massimo Fantoni Antimicrobial resistance is an urgent threat to public health and global development; in this scenario, the SARS-CoV2 pandemic has caused a major disruption of healthcare systems and practices. A narrative review was conducted on articles focusing on the impact of COVID-19 on multidrug-resistant gram-negative, gram-positive bacteria, and fungi. We found that, worldwide, multiple studies reported an unexpected high incidence of infections due to methicillin-resistant S. aureus, carbapenem-resistant A. baumannii, carbapenem-resistant Enterobacteriaceae, and C. auris among COVID-19 patients admitted to the...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
The objectives of the workshop are twofold: i) how&why different political systems that were put to the test engage and did what they did; ii) how health promotion in this pandemic play its role to ease the burden of populations. As of this writing, the pandemic is far from over. Therefore the added value of organizing this workshop is to help draw the many lessons that might need to be learned in a shared environment. The politics of COVID-19 during the pandemic warrant a multidisciplinary and multinational analysis. This knowledge can be useful as the world continues to fight COVID-19 and is equally important for thi...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsThe results of this study showed that some samples collected before the first autochthonous case was detected in Italy had antibodies reactive to the RBD of SARS-CoV-2. The Apulia region has been less severely affected by the first epidemic wave than the northern regions; however, these results suggest the spread of SARS-CoV-2 in the population in the late months of 2019. Since the majority of SARS-CoV-2 infections does not require hospitalization, it is possible that many of these have gone unnoticed.Key messagesThe spread of SARS-CoV-2 in the Italian population could have already occurred in late 2019.The exte...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsResults show the importance of establishing and maintaining ongoing contact among the preventive services, primary care providers and the population since trust is difficult to establish during an emergency.Key messagesOn of the most important finding for public health prevention efforts was the importance of influenza vaccine in predicting COVID.Having an agile system that can monitor changing attitudes will be important to altering the messaging and identifying changes in the characteristics of those hesitant or unwilling to be vaccinated.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
This study aimed to analyse the distribution of deaths in SARS-CoV-2 positive patients between pandemic phases and to evaluate the characteristics of COVID-19 patients deceased during the year.MethodsData on confirmed COVID-19 cases were collected from the recording system of the Department of Prevention of the Local Health Authority of Abruzzo Region, Italy. The course of the epidemic was stratified in 4 phases: the first wave (March-May 2020), the low incidence phase (June-September 2020), the second wave (October 2020-December 2021), and the variants spread phase in our region (January-March 2021).ResultsFrom March 2020...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
CONCLUSION: The different vaccine technologies like inactivation, attenuation, nucleic acid, viral vector, subunit and viral particle based techniques are employed to develop a safe and highly efficient vaccine. The progress in vaccine development for SARS-CoV2 is much faster in the history of science. Even though there exist lot of limitations, continuous efforts has put forward so as to develop highly competent and effective vaccine for many human and animal linked diseases due to its unlimited prospective. This review article focus on the historical outlook and the development of the vaccine as it is a crucial area of r...
Source: Biotechnology Journal - Category: Biotechnology Authors: Source Type: research
More News: COVID-19 | Epidemics | Epidemiology | France Health | Infectious Diseases | Microbiology | Pandemics | Respiratory Medicine | SARS