RNase A Inhibits Formation of Neutrophil Extracellular Traps in Subarachnoid Hemorrhage

Conclusion: Neutrophil extracellular trap formation following SAH originates in the ipsilateral SAS of the bleeding site and spreads gradually over time to basal, cortical, and periventricular areas in the parenchyma within 14days. Intravenous RNase application abrogates NET burden significantly in the brain parenchyma, underpinning a potential role in modulation of the innate immune activation after SAH.
Source: Frontiers in Physiology - Category: Physiology Source Type: research