Change in platelet indices in patients with Coronavirus disease-2019 (COVID-19): A reflection of platelet activation and contribution to immunothrombosis?
Int J Lab Hematol. 2021 Sep 14. doi: 10.1111/ijlh.13705. Online ahead of print.ABSTRACTIn December 2019, several cases of pneumonia of unknown aetiology were reported in Wuhan, China. The causative Coronavirus was subsequently isolated and named the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) and the disease, Coronavirus disease-2019 (COVID-19).1 COVID-19 related coagulopathy is a poor prognostic feature and reflects an underlying pathological process termed immunothrombosis.2 This process differs from infection-related disseminated intravascular coagulation (DIC) as it manifests primarily with thrombosis while thrombocytopenia and bleeding remain modest.3 The coagulation activation in COVID-19 relates to endothelial dysfunction, complement activation and ensuing cytokine storm with contributions from secondary infections and organ dysfunction.1,2 D-dimer values above 0.5 mg/L signifies poor patient outcomes.PMID:34519428 | DOI:10.1111/ijlh.13705
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AbstractInterest in self-management approaches to abortion with pills in the United States preceded the coronavirus disease 2019 (COVID-19) pandemic and has accelerated during this global health crisis. Coupled with the unclear future of legal abortion in the United States, clinical care providers need to be aware of the range of self-managed abortion approaches and of the varying levels of engagement with the formal health care system they entail. This article is intended to serve as a resource to inform providers of the current landscape of abortion with pills in the United States, while also describ...
Conclusions: We report a 100% occurrence of venous thromboembolism in critically ill patients supported by venovenous extracorporeal membrane oxygenation for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome using CT scan imaging despite a high target and close monitoring of anticoagulation.