PDE1 Inhibition Modulates Ca < sub > v < /sub > 1.2 Channel to Stimulate Cardiomyocyte Contraction

Conclusions: PDE1i enhances contractility by a PKA-dependent increase in Cav1.2 conductance with less total [Ca2+]i increase, and no significant changes in SR [Ca2+], myofilament Ca2+-sensitivity, or phosphorylation of critical EC-coupling proteins as observed with b-ARs and/or PDE3i. PDE1i could provide a novel positive inotropic therapy for heart failure without the toxicities of b-ARs and PDE3i.PMID:34521216 | DOI:10.1161/CIRCRESAHA.121.319828

Source: Cell Research - September 15, 2021 Category: Cytology Authors: Grace K Muller Joy Song Vivek Jani Yuejin Wu Ting Liu William Pd Jeffreys Brian O'Rourke Mark E Anderson David A Kass Source Type: research