Dopamine regulates adult neurogenesis in the ventricular ‐subventricular zone via dopamine D3 angiotensin type 2 receptor interactions

Model of the effects of dopamine in the proliferation of ventricular-subventricular zone cells. Dopamine, via D2-like receptors, upregulates angiotensin AT2 receptor expression, which mediates D2-induced cell proliferation. Dopamine, through D1-like receptors, decreases angiotensin AT1 receptor expression, and AT1 receptors inhibit cell proliferation. See Figure 5 for additional details. AbstractAdult neurogenesis is a dynamic and highly regulated process and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counterregulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigro-striatal system. We have previously demonstrated that angiotensin receptors regulate proliferation and generation of neuroblasts in the rodent V-SVZ. However, possible interactions between dopamine receptors and RAS in the V-SVZ and their role in alterations of neurogenesis in animal models of PD have not been investigated. In V-SVZ cultures, activation of dopamine receptors induced changes in the expression of angiotensin receptors. Moreover, dopamine, via D2-like receptors and particularly D3 receptors, increased generation of neurospheres derived from the V-SVZ and this effect ...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research