Targeted RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Temporal Arteries From Giant Cell Arteritis Cases Reveals Viral Signatures

Discussion
The detection of viral and immune activation pathways in GCA TAs supports a role for virus infection in GCA pathogenesis. In addition, the detection of viral pathways in control/VZV-positive TAs, along with vascular remodeling pathways, suggests that these samples may represent early infection with progression to clinical disease, depending on host and other environmental factors.

Source: Neurology Neuroimmunology and Neuroinflammation - September 7, 2021 Category: Neurology Authors: Bubak, A. N., Mescher, T., Mariani, M., Frietze, S. E., Hassell, J. E., Niemeyer, C. S., Como, C. N., Burnet, A. M., Subramanian, P. S., Cohrs, R. J., Mahalingam, R., Nagel, M. A. Tags: All Immunology, Vasculitis, Viral infections, All Cerebrovascular disease/Stroke, Gene expression studies Article Source Type: research