Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment

ConclusionsPRS could predict the conversion of MCI to dementia with a stronger association inAPOEε4 non-carriers thanAPOEε4 carriers. This indicates PRS as a potential genetic predictor particularly for MCI with noAPOEε4 alleles.

http://link.springer.com/10.1186/s40035-021-00259-w

Source: Translational Neurodegeneration - August 31, 2021 Category: Neurology Source Type: research