Paget ’s Disease of Bone: Osteoimmunology and Osteoclast Pathology

AbstractPurpose of ReviewThe purpose of this review is to recognize clinical features of Paget ’s disease of bone and to describe how the osteoclast, a myeloid-derived cell responsible for bone resorption, contributes to the disease.Recent FindingsRecent studies have identified several variants inSQSTM1,OPTN, and other genes that may predispose individuals to Paget ’s disease of bone; studies of these genes and their protein products have elucidated new roles for these proteins in bone physiology.SummaryUnderstanding the pathologic mechanisms in the Pagetic osteoclast may lead to the identification of future treatment targets for other inflammatory and autoimmune diseases characterized by abnormal bone erosion and/or osteoclast activation.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research