O-082 The ratio AMH/antral follicle count varies according to the etiologies of diminished ovarian reserve suggesting differences in follicular health

AbstractStudy questionDoes diminished ovarian reserve (DOR) and its etiology impact the AMH/AFC ratio?Summary answerAMH/AFC ratio varies according to the etiology of DOR in young women, suggesting different impact on the follicular health, and further oocyte quality.What is known alreadyAnti-M üllerian hormone and antral follicle count currently represent the two most accurate markers of the follicular ovarian status. Even though they may diagnose a reduction in the follicular stockpile, low values remain inefficient for predicting poor oocyte quality, in particular in young women. Since AMH is produced by the granulosa cells of follicles ranging from primary to small antral follicles, we hypothesized that the etiology of diminished ovarian reserve might differently impact the follicular health and their capacity of producing this peptide.Study design, size, durationFrom November 2018 to December 2021, we conducted a monocentric, retrospective study including a total of 484 infertile patients< 37 years with DOR.Participants/materials, setting, methodsAll patients underwent measurement of AMH levels and AFC. DOR was diagnosed according to the Bologna criteria (AMH< 1.1  ng/mL and AFC< 7). AMH/AFC ratio was compared to values obtained in 154 tubal or male infertility patients matched for age and BMI, with AMH and AFC in the normal ranges. This ratio was studied according to the etiology of DOR: genetic (n  = 26), post-chemotherapy (n = 102), idiopathic (n ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research