Repeated Ivermectin Treatment Induces Ivermectin Resistance in Strongyloides ratti by Upregulating the Expression of ATP-Binding Cassette Transporter Genes

In conclusion, IVM subtherapeutic doses induced IVM resistance in S. ratti by the F4 generation with corresponding upregulation of some ABC isoform genes. The study provides a model for inducing and assessing drug resistance in Strongyloides.PMID:34339389 | DOI:10.4269/ajtmh.21-0377

Source: The American Journal of Tropical Medicine and Hygiene - August 2, 2021 Category: Tropical Medicine Authors: Chatchawan Sengthong Manachai Yingklang Kitti Intuyod Ornuma Haonon Porntip Pinlaor Chanakan Jantawong Nuttanan Hongsrichan Thewarach Laha Sirirat Anutrakulchai Ubon Cha'on Paiboon Sithithaworn Somchai Pinlaor Source Type: research