Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion

Conclusions
Our results demonstrate that ventricular wall cardiomyocyte proliferation is subdivided into distinct regulatory phases. Each involves instructive cues that originate outside the heart and thereby act on the epicardium in an endocrine manner, a mode of regulation that is mostly unknown in embryogenesis.

Source: Cardiovascular Research - February 23, 2015 Category: Cardiology Authors: Shen, H., Cavallero, S., Estrada, K. D., Sandovici, I., Kumar, S. R., Makita, T., Lien, C.-L., Constancia, M., Sucov, H. M. Tags: Cardiac biology and remodelling Source Type: research