Tremor in Primary Monogenic Dystonia

This article reviews research articles reporting tremor in primary monogenic dystonia.Recent FindingsWe searched the MDS gene data and selected all research articles reporting tremor in primary monogenic dystonia. Tremor was reported in nine dystonia genes, namelyDYT-HPCA,DYT-ANO3,DYT-KCTD17,DYT-THAP1,DYT-PRKRA,DYT-GNAL,DYT-TOR1A,DYT-KMT2B, andDYT-SGCE in the descending order of its frequency. HPCA gene mutation is rare, but all reported patients had tremor. Similarly, tremor was reported in eight genes associated with dystonia parkinsonism, namelyDYT-SLC6A3,DYT-TH,DYT-SPR,DYT-PTS,DYT-GCH1,DYT-TAF1,DYT-QDPR, andDYT-SCL30A10 in the descending order of its prevalence.SummaryDYT-HPCA andDYT-ANO3 gene showed the highest prevalence of tremor in isolated dystonia, andDYT-SLC6A3 has the highest prevalence of tremor in combined dystonia.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research