Role of Interleukin-4 (IL-4) in respiratory infection and allergy caused by early life Chlamydia infection

In this study, Ch. pneumonia strain was propagated and cultured in HEp-2 cells according to the standard protocol and infant C57BL/6 mice which is around 3-4 weeks were infected to study the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. The study observed that IL-4 is linked with Chlamydia respiratory infection and its absence lowers respiratory infection. IL-4R α2 is also responsible for controlling the IL-4 signaling pathway and averted the progression of infection and inflammation. Furthermore, the IL-4 signaling pathway also influences the infection-induced AHR and aids in increasing AAD severity. STAT6 also promotes respiratory infection caused by Ch. pneumoniae and further enhanced their downstream process. Therefore, the study concludes that IL-4 is a potential target for preventing infection-induced AHR and severity of asthma.PMID:34226412 | DOI:10.4014/jmb.2104.04028
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Source Type: research