The Relationship Between Intact Parathyroid Hormone and 25-Hydroxyvitamin D in United Kingdom Resident South Asians and Whites: A Comparative, Cross-Sectional Observational Study
Horm Metab Res DOI: 10.1055/a-1521-5026Ethnic differences in intact parathyroid hormone (iPTH) at similar total 25
hydroxyvitamin D [25(OH)D] concentrations have been reported between US resident
Whites, Blacks, and Hispanics, but this has not been studied between South
Asians and Whites. We, therefore, compared the iPTH relationship to 25(OH)D in
UK resident South Asians and Whites. A comparative, cross-sectional
observational study in which demographic and laboratory data on South Asian and
White residents of Wolverhampton, UK were analyzed. Log-log models measured the
association between 25(OH)D and the interaction term of ethnicity and iPTH.
Seven hundred and seventy-two patients consisting of 315 white subjects (208
women) and 457 South Asian subjects (331 women) were studied. Compared to South
Asians, White subjects were older, had higher serum concentrations of 25(OH)D,
creatinine (lower eGFR), adjusted calcium and magnesium, but similar
concentrations of iPTH and phosphate. In an adjusted model, variables
significantly associated with 25(OH)D included age, creatinine, adjusted calcium
and ethnicity; but not iPTH and the interaction term of ethnicity and iPTH (beta
coefficient –0.071, 95% CI –0.209, 0.067,
p=0.32). In our study cohort, iPTH was not, per se, influenced by 25
(OH)D. We found no ethni...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Coley-Grant, Deon Jawad, Mohammed Ashby, Helen L. Cornes, Michael P. Kumar, Bharan Hallin, Magnus Nightingale, Peter G. Ford, Clare Gama, Rousseau Tags: Endocrine Care Source Type: research
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