Clinical, biochemical and genetic findings in adult patients with chronic hypophosphatasemia

ConclusionIn osteopenic/osteoporotic patients, single clinical or biochemical factors did not distinguish hypophosphatasemic patients harboring pALPL or bALPL from those harboring wtALPL. Occurrence of multiple clinical and biochemical features is predictive ofALPL anomalies, and, therefore, they should be carefully identified. Tamoxifen emerged as a hypophosphatasemic drug.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research