A a retrospective long-term study on age at menarche and menstrual characteristics in 85 young women with transfusion-dependent Β-thalassemia (tdt) born between 1965 and 1995

Conclusion: An early ICT in TDT patientswas associated to a normal " tempo " of pubertal onset and to a higher frequency of subsequent regular menstrual cycles. In TDT patients, who developed SA, a diagnosis of acquired central hypogonadism was made, mainly due to the chronic exposure to iron overload, however other potential causes linked to nutritional status,deficient levels of circulating nutrientsandthe chronic disease itself cannot be excluded. 
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Authors: Source Type: research