Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)
Conditions: Tuberculosis; Pulmonary Tuberculosis; HIV Coinfection Interventions: Drug: Isoniazid; Drug: Rifampicin; Drug: Ethambutol; Drug: Pyrazinamide; Drug: Metformin hydrochoride Sponsors: University of Massachusetts, Worcester; National Institute of Allergy and Infectious Diseases (NIAID); Aurum Institute; Singapore Immunology Network; University of Cape Town Not yet recruiting
Condition: Latent Tuberculosis Interventions: Behavioral: Usual Care; Behavioral: Video Directly Observed Therapy alone; Behavioral: Video Directly Observed Therapy plus Financial Incentives Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
AbstractPurpose of ReviewHypersensitivity reactions (HRs) to non-beta lactam antibiotics (NBLAs) have increased over the last years. Although NBLAs with their broad spectrum are widely used to treat various infections, knowledge about HRs due to these drugs is limited when compared to beta-lactam antibiotics (BLAs). Therefore, we aimed to discuss the structures, subgroups of various NBLAs including fluoroquinolones, macrolides, sulfonamides, first-line anti-tuberculosis agents, 5-nitroimidazols, aminoglycosides, glycopeptides, clindamycin, and tetracyclines, and we also reviewed epidemiology, clinical characteristics, cros...
Conditions: Tuberculosis, Multidrug-Resistant; Tuberculosis; Tuberculosis, Pulmonary Interventions: Drug: Linezolid 600 mg; Drug: Linezolid 1200 mg (QD); Drug: Linezolid 1200 mg (TIW); Drug: Bedaquiline 200 mg; Drug: Bedaquiline 100 mg; Drug: Delamanid 300 mg; Drug: Clofazimine 300 mg; Drug: Clofazimine 100 mg Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting