A Case of Acquired Coagulation Factor V Inhibitor that Was Successfully Treated with Oral Corticosteroid Therapy

Intern Med. 2021 Jun 12. doi: 10.2169/internalmedicine.7453-21. Online ahead of print.ABSTRACTAcquired coagulation factor V (FV) inhibitors are rare disorders in which antibodies against FV develop under various conditions. We herein report the case of a 71-year-old woman with FV inhibitor during radiochemotherapy for pancreatic cancer. Multiple purpuras suddenly appeared on her bilateral upper limbs with prolonged coagulation data (APTT 97.3 seconds). The FV activity was less than 3% and the FV inhibitor was positive (1.7 B.U./mL). Oral prednisolone induced a rapid normalization of the coagulation data and FV activity and a rapid disappearance of FV inhibitor within 7 days. Early diagnosis and treatment may therefore be important in cases of factor V inhibitor.PMID:34121013 | DOI:10.2169/internalmedicine.7453-21

Source: Internal Medicine - June 14, 2021 Category: Internal Medicine Authors: Yoshihiro Yokota Osamu Inatomi Minami Nakagawa Kazuki Kakuda Kousuke Hiroe Shigeki Sakai Rie Osaki Masaki Iwasa Masahiro Kawahara Katsuyuki Kito Akira Andoh Hiromichi Bamba Source Type: research